Background: Lipopolysaccharide (LPS) is a major component of Chlamydia spp, and of all Gram-negative bacteria. The role of LPS in alteration of sperm parameters is controversial. In this study quantification of Chlamydia-specific and general lipopolysaccharide in semen was correlated to semen quality. Materials and Methods: 255 male partners of infertile couples were recruited to produce urine ...

Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control...

Uptake transporters in brain microvascular endothelial cells (BMECs) are involved the penetration of basic (cationic) drugs such as diphenhydramine (DPHM) into brain. Lipopolysaccharide (LPS)-induced inflammation alters expression levels and activities uptake transporters, which change DPHM A microdialysis study showed that unbound brain-to-plasma partition coefficient ( K p,uu,brain ) for LPS ...

background : propylene glycol (1,2-propanediol, pg) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. while pg is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. objective: to evaluate the effect of pg in sepsis induced by the bacterial endotoxin lipopolysaccharide (lp...

objective: neuroimmune factors contribute on the pathogenesis of sickness behaviors. nigella sativa (ns) has anti-inflammatory, anti-anxiety and anti-depressive effects. in the present study, the effect of ns hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (lps) was investigated. materials and methods: the rats were divided into five groups (n=10 in each): (1) control...

conclusions in this study, the l-lps immune response of bovine cells was significant, indicating that tlr2 is the predominant receptor for l-lps. due to l-lps endotoxin-like activity, we found a strategy through using bmap-28 to prevent l-lps-induced tlr2-dependent immune activation in bovine cells. materials and methods in this study, l-lps-induced proinflammatory cytokine production in bovine...

Endotoxin lipopolysaccharide (LPS) is the most powerful and effective immunostimulant key virulence factor produced by Escherichia coli (E. coli) accountable for many of inflammatory changes observed during bovine mastitis. In this study, whole-transcriptomic gene in peripheral blood mononuclear cells (PBMCs) stimulated with LPS were compared to control group analyzed RNA sequencing. A total 35...

the present study investigated the effects of e. coli lipopolysaccharide (lps) induced mastitis model in rat on the activity of antioxidant enzyme systems. to achieve this purpose, e. coli lps were infused into the mammary gland of 12 rats 72 hr postpartum and compared with 12 rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. the antioxidant activ...